I'll just put this here for later inspiration . . . .

Call of Cthulhu (being aware of and addressing its inherent racism, obviously)
+
Bishoujo Senshi Sailor Moon
+
"Crazy" by Gnarls Barkley
(+
An optional infusion of Unknown Armies, maybe?)
=
One of the best ideas I've ever had!

And if you're wondering why, just hold this in the cosmic horror part of your brain:
In shoujo magical girl anime, the only thing that can save the world is love.

And then read the lyrics of "Crazy":
I remember when
I remember, I remember when I lost my mind
There was something so pleasant about that place
Even your emotions have an echo in so much space
And when you're out there, without care
Yeah I was out of touch
But it wasn't because I didn't know enough
I just knew too much
Does that make me crazy?
Does that make me crazy?
Does that make me crazy?
Possibly
And now that you are having the time of your life
Well think twice
That's my only advice
Come on now, who do you
Who do you, who do you
Who do you think you are?
Ha ha ha, bless your soul
You really think you're in control?
Well
I think you're crazy
I think you're crazy
I think you're crazy
Just like me
My heroes had the heart
To lose their lives out on a limb
And all I remember, is thinking
I wanna be like them
Mm hmm ever since I was little
Ever since I was little it looked like fun
And it's no coincidence I've come
And I can die when I'm done
Maybe I'm crazy
Maybe you're crazy
Maybe we're crazy
Probably ooh hmm

As for Unknown Armies, I'll just remind you of its old tagline:  You Did It.